Remember, these videos were recorded on a test map, where I'm not under any pressure from the horde surrounding and teammates randomly shooting. Swat, Commando, Medic and Firebug are not supposed to kill them but I still listed them in case you need to do something in an emergency. They all have their advantages & disadvantages. Primary Large Zed killers are Demolitionist and Sharpshooter, while the secondaries are Gunslinger, Support and Berserker.
Mandatory skills and weapons are outlined with yellow color. I listed the loadout and skills needed to perform each kill. Level 25 is required, but you can still perform some of these methods to a degree even if your level is lower, especially on lower difficulties. Everything is based on 6 players Hell on Earth difficulty, so they can be applied on lower difficulties too, just easier.